Maximum Strength NoDoz pills are fast acting alertness pills that are as safe as coffee. Each No Doz pill contains 200 mg of caffeine. 1/2 to 1 pill contains the same amount of caffeine as one cup of coffee. They suggest you take 1/2 to 1 No Doz caplet not more than every 3 to 4 hours to restore mental alertness or wakefulness when experiencing fatigue or drowsiness.