Afrin Original Nasal Spray delivers fast, powerful congestion relief. Afrin Original provides maximum strength relief for twelve hours. Afrin helps ease your cold and allergy symptoms. Afrin is the #1 doctor recommended brand of nasal spray. Afrin works hard to temporarily relieve uncomfortable sinus congestion and pressure. Afrin nasal spray shrinks swollen nasal membranes so you can breathe more freely. Afrin Original Nasal Spray contains the active ingredient oxymetazoline hydrochloride (0.05%). This bottle contains one fluid ounce of Afrin.