Afrin Nasal Spray Afrin Nasal Decongestant Spray Afrin Nasal Decongestant Spray starts to work in seconds providing up to 12 hours of nasal congestion relief with no drowsiness. Afrin Nasal Spray is Number one in doctor and Pharmacist recommendations. Afrin Nasal Decongestant clears stuffy noses fast, with a unique formula that soothes as it relieves. The active ingredient in Afrin Nasal Decongestant Spray is Oxymetazoline Hydrochloride. Each bottle contains one fluid ounce (30 ml).