Abreva Abreva Cold Sore Treatment Abreva Docosanol 10% Cream is a cold sore/fever blister treatment that shortens healing time and duration of symptoms. Abreva is used on cold sores/fever blisters on the face or lips, and relieves the symptoms of tingling, pain, burning and/or itching. Abreva cream formula dries clear. Each tube is Net Weight 2.0g (.07 oz.).